Depends.
a: Is the Bears defense from games 1-7 going to show up? or is the Bears defense from games 8-16 going to show up?
b: Is Grossman going to throw interceptions or completions?
c: Is Urlacher going to get to Manning more than twice in 4 quarters?
d: Will Vinatieris' foot be ready?
e: Will the Colts offense capitalize on receiving, or will they have 10+ dropped, wide open, passes?
My gut says Colts, but it could go either way depending on who shows up and how they play.
edit: What I do know is that the Colts are favored by 7 points, nation-wide, to win. And Manning deserves a ring from all the trash talk and bullshit non-fans spew throughout the season.
The real question here is...
Is B actually going to watch it?