At around that goal, I'd just get some ARP rod-bolts, Heat-treat your rods, forged pistons/rings and have it all balanced and assemble it right with close tolerances. Honda cranks are pretty stout and usually don't give up that easy. Have a good pocket porting on the head with a mild cam. Have your injectors flowed by a reputable shop.
Once you build up a good bottom end, you will be less worried about it later when you add more stuff to it. (you know you will..)
Most important thing is keep it all CLEAN when you build it and if it will sit for a while, Bag it up. You don't want to disassemble it, re-clean and reassemble again.
Just my .02
E