first you need a custom intake manifold, and since the honda engine is small displacement, you would probably be much beter off with a smaller carb, you could still use a four barrel but not 500 CFM.
it probably would not run well except high RPM either. not very streetable.
I say go for it and be the first to rock a holley on a honda!
even cooler if you stick the induction stack out the hood.