High CR + Boost + 100 octane gas + good tune = One happy, fast mamma jamma.
High CR + Boost + crap gas + any tune = preignition = bye bye bottom end.
The end.
Both high compression and boost push the upper limits of normal pump gas' resistance to preignition, or 'knock'. This not only means that the gas is more likely to autoignite before the spark, but the increased cylinder pressure will also increase flame temps and flame speed. You really don't want to mess with high compression and boost unless you are using race fuel. Not to mention a good set of sleeves is NOT optional. But, and a big BUT, if you have a bit of knowledge about the properties of the gas you are intending to use, and can work out the thermodynamic cycle of what you propose to design, you CAN build a safe, reliable, high compression, super/turbo charged engine. And it WILL be fast. Have fun, that's what I'm doing for my next build, not super high compression though, probably close to 11:1.